Constitutively active SPAK causes hyperkalemia by activating NCC and remodeling distal tubules
Aberrant activation of with no lysine (WNK) kinases causes familial hyperkalemic
hypertension (FHHt). Thiazide diuretics treat the disease, fostering the view that
hyperactivation of the thiazide-sensitive sodium-chloride cotransporter (NCC) in the distal
convoluted tubule (DCT) is solely responsible. However, aberrant signaling in the
aldosterone-sensitive distal nephron (ASDN) and inhibition of the potassium-excretory renal
outer medullary potassium (ROMK) channel have also been implicated. To test these ideas …
hypertension (FHHt). Thiazide diuretics treat the disease, fostering the view that
hyperactivation of the thiazide-sensitive sodium-chloride cotransporter (NCC) in the distal
convoluted tubule (DCT) is solely responsible. However, aberrant signaling in the
aldosterone-sensitive distal nephron (ASDN) and inhibition of the potassium-excretory renal
outer medullary potassium (ROMK) channel have also been implicated. To test these ideas …