T regulatory cell therapy in transplantation: stability, localization and functional specialization
KG MacDonald, PC Orban… - Current opinion in organ …, 2012 - journals.lww.com
KG MacDonald, PC Orban, MK Levings
Current opinion in organ transplantation, 2012•journals.lww.comKnowledge of how Tregs work in transplantation comes from studies that do not recapitulate
how these cells will be used in humans. There is a need to develop better preclinical models
to study how the in-vivo function of human Tregs can be optimized to ensure they can meet
the challenge of inducing transplantation tolerance.
how these cells will be used in humans. There is a need to develop better preclinical models
to study how the in-vivo function of human Tregs can be optimized to ensure they can meet
the challenge of inducing transplantation tolerance.
Summary
Knowledge of how Tregs work in transplantation comes from studies that do not recapitulate how these cells will be used in humans. There is a need to develop better preclinical models to study how the in-vivo function of human Tregs can be optimized to ensure they can meet the challenge of inducing transplantation tolerance.
Lippincott Williams & Wilkins