CCR5Δ32 mutation and HIV infection: basis for curative HIV therapy
K Allers, T Schneider - Current opinion in virology, 2015 - Elsevier
Highlights•Homozygous CCR5Δ32/Δ32 mutation renders cells deficient of CCR5 surface
expression.•Naturally CCR5-deficient immune cells are resistant to infection with CCR5-
tropic HIV.•Allogeneic transplantation of CCR5-deficient stem cells have cured a patient of
HIV.•Novel gene editing methods that aim to mimic natural CCR5 deficiency are
promising.•Further development is required to enable curative HIV therapy.The C–C
chemokine receptor 5 (CCR5) is expressed on potential human immunodeficiency virus …
expression.•Naturally CCR5-deficient immune cells are resistant to infection with CCR5-
tropic HIV.•Allogeneic transplantation of CCR5-deficient stem cells have cured a patient of
HIV.•Novel gene editing methods that aim to mimic natural CCR5 deficiency are
promising.•Further development is required to enable curative HIV therapy.The C–C
chemokine receptor 5 (CCR5) is expressed on potential human immunodeficiency virus …