[HTML][HTML] The gut-enriched Krüppel-like factor (Krüppel-like factor 4) mediates the transactivating effect of p53 on the p21 WAF1/Cip1 promoter
W Zhang, DE Geiman, JM Shields, DT Dang… - Journal of Biological …, 2000 - ASBMB
An important mechanism by which the tumor suppressor p53 maintains genomic stability is
to induce cell cycle arrest through activation of the cyclin-dependent kinase inhibitor p21
WAF1/Cip1 gene. We show that the gene encoding the gut-enriched Krüppel-like factor
(GKLF, KLF4) is concurrently induced with p21 WAF1/Cip1 during serum deprivation and
DNA damage elicited by methyl methanesulfonate. The increases in expression of both Gklf
and p21 WAF1/Cip1 due to DNA damage are dependent on p53. Moreover, during the first …
to induce cell cycle arrest through activation of the cyclin-dependent kinase inhibitor p21
WAF1/Cip1 gene. We show that the gene encoding the gut-enriched Krüppel-like factor
(GKLF, KLF4) is concurrently induced with p21 WAF1/Cip1 during serum deprivation and
DNA damage elicited by methyl methanesulfonate. The increases in expression of both Gklf
and p21 WAF1/Cip1 due to DNA damage are dependent on p53. Moreover, during the first …