Interferons induce CXCR3-cognate chemokine production by human metastatic melanoma
LT Dengel, AG Norrod, BL Gregory… - Journal of …, 2010 - journals.lww.com
Immune-mediated cancer regression requires tumor infiltration by antigen-specific effector T
cells, but lymphocytes are commonly sparse in melanoma metastases. Activated T cells
express CXCR3, whose cognate chemokines are CXCL9/MIG, CXCL10/IP-10, and
CXCL11/I-TAC. Little is known about expression of these chemokines in lymph node (LN)
metastases of melanoma. We evaluated whether metastatic melanoma induces these
CXCR3-cognate chemokines in human LN-derived tissues. In addition, as these …
cells, but lymphocytes are commonly sparse in melanoma metastases. Activated T cells
express CXCR3, whose cognate chemokines are CXCL9/MIG, CXCL10/IP-10, and
CXCL11/I-TAC. Little is known about expression of these chemokines in lymph node (LN)
metastases of melanoma. We evaluated whether metastatic melanoma induces these
CXCR3-cognate chemokines in human LN-derived tissues. In addition, as these …
