A complex Polycomb issue: the two faces of EZH2 in cancer
H Hock - Genes & development, 2012 - genesdev.cshlp.org
H Hock
Genes & development, 2012•genesdev.cshlp.orgIn the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651–656)
demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic
leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that
similar mechanisms are involved in human T-ALL. These data contrast with previous
findings showing that increased EZH2 activity promotes cancer.
demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic
leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that
similar mechanisms are involved in human T-ALL. These data contrast with previous
findings showing that increased EZH2 activity promotes cancer.
In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651–656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer.
genesdev.cshlp.org