Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly
T Fukuda, A Tokunaga, R Sakamoto… - Molecular and Cellular …, 2011 - Elsevier
Histone methylation is the important transcription regulatory system that affects mammalian
development and cell differentiation. Alterations in epigenetic gene regulation are
associated with disease. Fbxl10 (F-box and leucine-rich repeat protein 10) is a JmjC domain-
containing histone demethylase. Although Fbxl10 has been implicated in cell cycle
regulation, cell death, senescence, and tumorigenesis, these functions are controversial and
its physiological function is unclear. To determine the in vivo function of Fbxl10, in this study …
development and cell differentiation. Alterations in epigenetic gene regulation are
associated with disease. Fbxl10 (F-box and leucine-rich repeat protein 10) is a JmjC domain-
containing histone demethylase. Although Fbxl10 has been implicated in cell cycle
regulation, cell death, senescence, and tumorigenesis, these functions are controversial and
its physiological function is unclear. To determine the in vivo function of Fbxl10, in this study …