Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes
M Pykäläinen, R Kinos, S Valkonen, P Rydman… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Immune responses characterized by TH2 type cells and IgE are important
for the development of asthma and atopy. The transcription factors STAT6, GATA3, and
STAT4 mediate the cytokine-induced development of naïve CD4+ T cells into either TH1 or
TH2 type. OBJECTIVE: We studied genetic variation of the STAT6, GATA3, and STAT4
genes and examined whether single nucleotide polymorphisms (SNPs) in these loci were
associated with asthma or serum high IgE levels in the Finnish asthmatic families …
for the development of asthma and atopy. The transcription factors STAT6, GATA3, and
STAT4 mediate the cytokine-induced development of naïve CD4+ T cells into either TH1 or
TH2 type. OBJECTIVE: We studied genetic variation of the STAT6, GATA3, and STAT4
genes and examined whether single nucleotide polymorphisms (SNPs) in these loci were
associated with asthma or serum high IgE levels in the Finnish asthmatic families …