A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ
Y Hashimoto, T Niikura, H Tajima… - Proceedings of the …, 2001 - National Acad Sciences
Y Hashimoto, T Niikura, H Tajima, T Yasukawa, H Sudo, Y Ito, Y Kita, M Kawasumi…
Proceedings of the National Academy of Sciences, 2001•National Acad SciencesThrough functional expression screening, we identified a gene, designated Humanin (HN)
cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by
multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without
effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was
transcribed to the corresponding polypeptide and then was secreted into the cultured
medium. The rescue action clearly depended on the primary structure of HN. This …
cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by
multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without
effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was
transcribed to the corresponding polypeptide and then was secreted into the cultured
medium. The rescue action clearly depended on the primary structure of HN. This …
Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.
National Acad Sciences