[HTML][HTML] SIRT5 prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3
Y Wang, Y Zhu, S Xing, P Ma, D Lin - Cell Stress and Chaperones, 2015 - Elsevier
Cigarette smoking plays an important role in increased incidence of chronic obstructive
pulmonary disease (COPD). The underlying mechanism in which cigarette smoking induced
impairment of lung epithelial cells is still unknown. SIRT5 is a nicotinamide adenine
dinucleotide (NAD+)-dependent protein deacetylase, which has been implicated in the
regulation of metabolism, stress responses, and aging. Forkhead box O 3 (FOXO 3) belongs
to the O subclass of the forkhead family of transcription factors. It is also involved in …
pulmonary disease (COPD). The underlying mechanism in which cigarette smoking induced
impairment of lung epithelial cells is still unknown. SIRT5 is a nicotinamide adenine
dinucleotide (NAD+)-dependent protein deacetylase, which has been implicated in the
regulation of metabolism, stress responses, and aging. Forkhead box O 3 (FOXO 3) belongs
to the O subclass of the forkhead family of transcription factors. It is also involved in …