[HTML][HTML] The role of mitochondria in the development and progression of lung cancer
ER Roberts, KJ Thomas - Computational and Structural Biotechnology …, 2013 - Elsevier
ER Roberts, KJ Thomas
Computational and Structural Biotechnology Journal, 2013•ElsevierThe influence of mitochondria in human health and disease is a rapidly expanding topic in
the scientific literature due to their integral roles in cellular death and survival. Mitochondrial
biology and alterations in function were first linked to cancer in the 1920s with the discovery
of the Warburg effect. The utilization of aerobic glycolysis in ATP synthesis was the first of
many observations of metabolic reprogramming in cancer. Mitochondrial dysfunction in
cancer has expanded to include defects in mitochondrial genomics and biogenesis …
the scientific literature due to their integral roles in cellular death and survival. Mitochondrial
biology and alterations in function were first linked to cancer in the 1920s with the discovery
of the Warburg effect. The utilization of aerobic glycolysis in ATP synthesis was the first of
many observations of metabolic reprogramming in cancer. Mitochondrial dysfunction in
cancer has expanded to include defects in mitochondrial genomics and biogenesis …
Abstract
The influence of mitochondria in human health and disease is a rapidly expanding topic in the scientific literature due to their integral roles in cellular death and survival. Mitochondrial biology and alterations in function were first linked to cancer in the 1920s with the discovery of the Warburg effect. The utilization of aerobic glycolysis in ATP synthesis was the first of many observations of metabolic reprogramming in cancer.
Mitochondrial dysfunction in cancer has expanded to include defects in mitochondrial genomics and biogenesis, apoptotic signaling and mitochondrial dynamics. This review will focus on the role of mitochondria and their influence on cancer initiation, progression and treatment in the lung.
Elsevier